Researchers report progress towards understanding which genes play the biggest roles in psoriasis.

Participants said the lesions caused similar or more distress than skin conditions like acne or psoriasis.

Researchers say finding predictive signs in a patient’s genetic profile is a step toward applying precision medicine to complex inflammatory skin diseases.

When tested in mice, psoriasis became more severe when more interferon kappa was present.

The finding will indicate how aggressively physicians should treat patients with the associated condition.

Inhibiting IRE1α, a molecule activated by the endoplasmic reticulum in neutrophils, counters disease progression in lupus mice.